Also known as:

NMN Description:

Nicotinamide Mononucleotide (NMN) is a naturally occurring molecule found in various foods, such as broccoli, avocado, and edamame. NMN is a derivative of niacin (vitamin B3) and serves as a precursor to Nicotinamide Adenine Dinucleotide (NAD+), an essential coenzyme in cells that plays a vital role in energy production, DNA repair, and cellular signaling. NAD+ levels decrease with age, and this decline has been associated with age-related health issues and a decrease in overall health.

Most Notable Benefits:

• Increased NAD+ levels: NMN supplementation has been shown to boost NAD+ levels, which may have a positive impact on energy production, mitochondrial function, and overall cellular health.
• Improved metabolic function: By increasing NAD+ levels, NMN can enhance metabolic function, which may lead to improved endurance and exercise performance.
• Enhanced DNA repair: NMN has been linked to improved DNA repair, which may help protect against age-related diseases and damage to cells caused by environmental factors and natural aging processes.
• Reduced inflammation and oxidative stress: NMN may reduce inflammation and oxidative stress, both of which contribute to aging and age-related diseases.

Known Conflicts or Potential Isssues:

There are no known significant conflicts or potential issues when taking NMN with other medications. However, it is essential to consult your healthcare provider before starting any new supplement, especially if you are currently taking medications or have pre-existing health conditions.

Why Dr. Sinclair takes NMN in his daily regimen:

In his book “Lifespan: Why We Age and Why We Don’t Have To,” Dr. David Sinclair explains that he takes NMN as part of his daily regimen to boost NAD+ levels. He believes that increasing NAD+ levels may help counteract the natural decline that occurs with age, thus supporting cellular health, energy production, and potentially promoting overall health and longevity.

REPUTABLE SOURCES:

• Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., … & Imai, S. I. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism, 24(6), 795-806. Link
• Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metabolism, 27(3), 529-547. Link
• Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., … & Tsubota, K. (2020). Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocrine Journal, 67(2), 153-160. Link

SUPPORTING PDFs:

• Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice
• Therapeutic potential of NAD-boosting molecules: the in vivo evidence
• Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

These studies and sources provide valuable information about the potential benefits of NMN supplementation, particularly in relation to NAD+ levels, cellular health, and aging. It is essential to note that while NMN shows promise as an anti-aging and performance-enhancing supplement, more research is needed to fully understand its long-term effects and optimal dosages in humans.