Resveratrol

Also known as:

3,5,4′-trihydroxy-trans-stilbene
trans-Resveratrol

Resveratrol Description:

Resveratrol is a naturally occurring polyphenol compound found in various plant sources, including the skin of red grapes, blueberries, raspberries, and peanuts. It is a potent antioxidant and has gained attention for its potential health benefits, particularly in the context of anti-aging and cardiovascular health.

Most Notable Benefits:

Antioxidant properties: Resveratrol acts as a powerful antioxidant, neutralizing free radicals that contribute to cellular damage and aging.
Anti-inflammatory effects: Resveratrol has demonstrated anti-inflammatory properties, which may help reduce chronic inflammation and its associated health risks.
Improved cardiovascular health: Resveratrol has been linked to improved cardiovascular function and reduced risk of heart disease by promoting healthy blood vessels and circulation.
Enhanced mitochondrial function: Resveratrol has been shown to improve mitochondrial function, which may lead to increased energy production and improved athletic performance.
Activation of longevity pathways: Resveratrol is known to activate the sirtuin pathway (SIRT1), which is associated with longevity and improved cellular health.

Known Conflicts or Potential Isssues:

Resveratrol may interact with anticoagulant and antiplatelet medications, such as warfarin and aspirin, increasing the risk of bleeding. Consult your healthcare provider before taking resveratrol if you are on these medications.
Some individuals may experience gastrointestinal side effects, such as nausea or diarrhea, when taking high doses of resveratrol. If side effects are severe, consider reducing the dosage or discontinuing use.

Why Dr. Sinclair takes NMN in his daily regimen:

In his book “Lifespan: Why We Age and Why We Don’t Have To,” Dr. David Sinclair explains that he takes resveratrol daily because it activates the SIRT1 gene, a key component of the longevity pathway. Activation of this pathway is associated with improved cellular health, reduced inflammation, and enhanced mitochondrial function, all of which contribute to overall health and longevity.

REPUTABLE SOURCES:

- Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., … & Sinclair, D. A. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444(7117), 337-342. Link
- Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., … & Schrauwen, P. (2011). Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metabolism, 14(5), 612-622. Link
- Kennedy, D. O., Wightman, E. L., Reay, J. L., Lietz, G., Okello, E. J., Wilde, A., & Haskell, C. F. (2010). Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. The American Journal of Clinical Nutrition, 91(6), 1590-1597. Link

SUPPORTING PDFs:

These studies and sources provide evidence for the potential health benefits of resveratrol, particularly in relation to anti-aging, athletic performance, and cardiovascular health. As with any supplement, it is crucial to consult your healthcare provider before starting resveratrol supplementation, especially if you have pre-existing health conditions or are taking medications. More research is needed to fully understand the long-term effects and optimal dosages of resveratrol in humans.